Isethi yemithetho emisha yamazwe ngamazwe ishintsha ngokujulile uchungechunge lokuhlinzekwa kwempahla yezinwele emhlabeni wonke kulo nyaka. I-United States ibala izandiso zezinwele njengempahla yezimonyo, edinga ukubhaliswa kwefekthri nokuhlolwa kokuphepha komkhiqizo. Imithetho ye-EU ebuyekeziwe ye-REACH ikhawulela izithasiselo zamakhemikhali eziyingozi ezisetshenziselwa ukudaya izinwele kanye nokucutshungulwa. Zonke izimboni zezinwele ezigxile ekuthumeleni kwamanye amazwe zidinga ukuthuthukisa ukulandeleka kwezinto ezingavuthiwe kanye nokuthobelana nesithako samakhemikhali ukuze kwenelise amazinga ezimakethe zaphesheya kwezilwandle.