Iseti yemithetho emitsha yamazwe ngamazwe itshintsha ngokunzulu ikhonkco lonikezelo lwempahla yeenwele kwihlabathi kulo nyaka. I-United States idwelisa izandiso zeenwele njengezinto zokuthambisa, ezifuna ukubhaliswa kwefektri kunye nokuhlolwa kokhuseleko lwemveliso. Imithetho ye-EU ehlaziyiweyo ye-REACH inqanda izongezo zekhemikhali ezinobungozi ezisetyenziselwa ukudaywa kweenwele kunye nokulungiswa kwasemva. Zonke iifektri zeenwele ezijolise kumazwe angaphandle kufuneka ziphucule ukulandeleka kwempahla ekrwada kunye nokuthotyelwa kwezithako zekhemikhali ukwanelisa imigangatho yemarike yaphesheya kolwandle.